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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM2
All Species:
32.73
Human Site:
S285
Identified Species:
51.43
UniProt:
P31350
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31350
NP_001025.1
389
44878
S285
K
H
L
V
H
K
P
S
E
E
R
V
R
E
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100144
351
40744
I254
S
E
E
R
V
R
E
I
I
V
D
A
V
Q
I
Dog
Lupus familis
XP_540076
394
45449
S290
K
H
L
V
H
K
P
S
E
Q
R
V
K
E
I
Cat
Felis silvestris
Mouse
Mus musculus
P11157
390
45077
A286
K
H
L
V
H
K
P
A
E
Q
R
V
R
E
I
Rat
Rattus norvegicus
Q4KLN6
390
45020
S286
K
H
L
V
H
K
P
S
E
Q
R
V
K
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506085
394
45462
S290
K
H
L
V
H
K
P
S
E
E
R
V
K
E
I
Chicken
Gallus gallus
XP_419948
384
44421
S280
K
H
L
I
R
K
P
S
E
E
R
V
K
E
I
Frog
Xenopus laevis
NP_001080772
386
44577
S282
R
H
L
V
H
K
P
S
E
E
R
V
V
Q
L
Zebra Danio
Brachydanio rerio
P79733
386
44575
S282
K
H
L
I
N
K
P
S
E
E
T
V
K
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48592
393
45096
K289
Q
H
L
V
Q
R
P
K
R
E
R
I
I
E
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42170
381
44271
T277
S
K
L
Q
K
K
L
T
Q
Q
R
I
Y
D
I
Sea Urchin
Strong. purpuratus
XP_780110
412
47263
D303
K
H
L
N
N
K
P
D
E
E
H
V
Q
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q6Y657
333
38312
I236
I
V
C
D
A
V
E
I
E
R
E
F
V
C
D
Baker's Yeast
Sacchar. cerevisiae
P09938
399
46129
D292
A
H
L
K
N
K
P
D
P
A
I
V
E
K
I
Red Bread Mold
Neurospora crassa
Q9C167
410
46679
S293
S
H
L
N
N
R
P
S
K
Q
L
I
Q
E
I
Conservation
Percent
Protein Identity:
100
N.A.
72.4
95.4
N.A.
91.2
89.7
N.A.
90.6
88.4
84
83.5
N.A.
68.9
N.A.
59.9
67.9
Protein Similarity:
100
N.A.
82
96.4
N.A.
95.3
94.6
N.A.
95.4
94
91
90.7
N.A.
79.3
N.A.
74.8
77.6
P-Site Identity:
100
N.A.
6.6
86.6
N.A.
86.6
86.6
N.A.
93.3
80
73.3
66.6
N.A.
53.3
N.A.
26.6
60
P-Site Similarity:
100
N.A.
20
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
73.3
N.A.
60
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.8
58.4
64.3
Protein Similarity:
N.A.
N.A.
N.A.
69.9
71.4
75.8
P-Site Identity:
N.A.
N.A.
N.A.
6.6
40
40
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
53.3
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
0
0
7
0
7
0
7
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
0
7
0
0
0
14
0
0
7
0
0
7
7
% D
% Glu:
0
7
7
0
0
0
14
0
67
47
7
0
7
54
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% G
% His:
0
80
0
0
40
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
7
0
0
14
0
0
0
14
7
0
7
20
7
0
87
% I
% Lys:
54
7
0
7
7
74
0
7
7
0
0
0
34
14
0
% K
% Leu:
0
0
87
0
0
0
7
0
0
0
7
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
14
27
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
80
0
7
0
0
0
0
0
0
% P
% Gln:
7
0
0
7
7
0
0
0
7
34
0
0
14
14
0
% Q
% Arg:
7
0
0
7
7
20
0
0
7
7
60
0
14
0
0
% R
% Ser:
20
0
0
0
0
0
0
54
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% T
% Val:
0
7
0
47
7
7
0
0
0
7
0
67
20
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _